PhD position in cancer chromatin biology

About this job

About the position Applications are invited to apply for a 100% 3-year PhD position in cancer chromatin and structural biology in the research group of Prof. Philippe Collas, project group of Dr. Marie Rogne, at the Department of Molecular Medicine, Division of Biochemistry, Institute of Basic Medical Sciences, University of Oslo ( Collas Lab ). The position is funded through the Norwegian Research Council. The successful candidate will collaborate with partners at the Technical University of Denmark (DTU). Within the Institute, the Division of Biochemistry consists of a young and active community of nine research groups working on cancer biology, chromatin and nuclear dynamics, nuclear architecture, membrane trafficking, and adipocyte, muscle and vascular biology, using human, fly and mouse models. More about the position The overall goal of the project is to establish knowledge of the innovative therapeutic potential of microproteins in advanced prostate cancer. In this context, the successful applicant will, in collaboration with the rest of the team and external partners, examine how specific microproteins regulate the activity of the transcription factor SOX2 using cell-based and epigenomic assays, and resolve the SOX2 microprotein complex using a crystallographic approach. To be employed as a PhD Research Fellow, admission to the Medical Faculty's PhD program is required, or there must be a binding agreement for admission. Normally, one must apply for admission within 3 months after the start of the research project leading to the Ph.D. degree. The PhD fellow is expected to complete the project within three years. Responsibilities Plan and execute experiments in genomics (RNA‑seq/ATAC‑seq/ChIP‑seq), proteomics and recombinant protein expression/purification. Design and perform cellular assays. Maintain accurate electronic lab records, analyze and interpret data. Present results at group meetings and scientific platforms, and contribute to manuscript writing. Take the required doctoral coursework. Qualifications Qualification requirements To be admitted to the PhD programmes at the University of Oslo, an applicant must have a five year master's degree or equivalent studies in molecular biology, epigenetics or a related field, minimum grade B (ECTS grading scale) or equivalent. Experience in cell and molecular biology, including vector design, cloning, engineering cell lines, cell-based assays Knowledge and experience in chromatin, transcriptional regulation or microproteins. Fluent oral and written communication skills in English. Desired qualifications Experience in proteomics (wet-lab and data analysis) will be a strong advantage. Some background in bioinformatics analysis of epigenetic data (RNA-seq, ChIP-seq, etc) is a plus. Experience with electronic lab-journal systems (e.g. Benchling or E-lab) is valued. Previous publishing experience is positive. Personal skills You are independent but enjoy working as part of a team towards shared, ambitious goals. You are positive, structured, solution-driven and accurate, with grit and determination. You have a result-oriented mindset and contribute scientific and practical inputs to projects. You are eager to learn and develop your scientific thinking. Communication with other team members is important: you will therefore have excellent communication and collaborative skills. Employment in the position is based on a comprehensive assessment of all qualification requirements applicable to the position, including personal qualifications. We need different perspectives in our work UiO is an open and internationally oriented comprehensive university that strives to be an inclusive and diverse workplace and academic environment. You can read more about UiO’s work on equality, inclusion, and diversity at uio.no. We fulfill our mission most effectively when we draw upon our variety of experiences, backgrounds, and perspectives. We are looking for great colleagues - could you be the next one? We will provide appropriate accommodations should you need them. Relevant adjustments may include modifications to working hours, task adaptations, digital, technical, or physical adjustments, or other practical measures. If you have an immigrant background, a disability, or CV gaps, we encourage you to indicate this in the job application portal. We always invite at least one qualified candidate from each group for an interview. In this context, disability is defined as an applicant who identifies as having a disability that requires workplace or employment-related accommodations. For more details about the requirements, please refer to the Employer portal (Norwegian). The selections made in the job application portal are used for anonymized statistics that all state employers include in their annual reports. More information about gender equality initiatives at UiO can be found here. We hope you will apply for the position with us. We offer Exciting and meaningful tasks in a

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