Internship - ADC modeling (m/f/d)
Merck KGaA · Corsier-sur-Vevey
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- Company
- Merck KGaA
- Location
- Corsier-sur-Vevey
- Employment type
- Full-time
- Posted
- September 30, 2026
About this job
Start Date: 1st January 2027 Duration: 6 months Localisation: Corsier-sur-Vevey Role Level: Internship Conjugation of monoclonal antibody with a drug linker is a critical step in the development of antibody-drug bioconjugates. Today, offline analytical methods provide detailed information on the reaction, but they are time-consuming and don’t enable continuous process monitoring.The objective of this project is to develop a proof of concept for a hybrid soft sensor combining UV-Vis spectroscopy to provide fast, information-rich process measurements; a kinetic reaction model to describe the evolution of the conjugation species; an Extended Kalman Filter to combine measurements and model predictions while accounting for their respective uncertainties.…
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