Postdoctoral Research Fellow in epigenetics at the K.G Jebsen Centre of Obesity Research (CORA)

About this job

About the position Applications are invited for a 3-year position as postdoctoral researcher in epigenetics and obesity research at the newly established K.G Jebsen Centre of Obesity ReseArch (CORA). The position will be affiliated to Yvonne Böttcher’s research group at the Department of Clinical Molecular Biology (EpiGen) at Institute of Clinical Medicine, UiO, physically located at Campus Ahus (Akershus University Hospital). The project aims at investigating molecular mechanisms underlying weight regain and long-term weight loss maintenance using advanced molecular biology techniques. In particular, the project will investigate amongst other the concept of epigenetic memory of obesity in humans and closely collaborate with clinical environments involved in treatment of obesity The applicant will be involved in tasks related to epigenetic and epitranscriptomic mechanisms potentially being implicated in the regulation of human body weight and adipose tissue biology in general. We are looking for a candidate with extensive hands-on training on a broad spectrum of multiomics analyses in adipose tissue. The applicant will join a team with long-standing experience in translational obesity research whilst other groups in the department Is generally working on translational biomedical research focusing on Alzheimer´s, and cancer research in a precision medicine perspective. Project description Obesity is a growing health problem worldwide. Metabolic surgery or use of GLP-1R analoga are efficient methods to induce significant weight loss in individuals with obesity. However, many individuals struggle to maintain a healthier body weight and often suffer from regain weight after treatment. The newly established K.G. Jebsen Center for obesity research ( CORA ), lead by Prof. Yvonne Böttcher, aims to understand the biological mechanisms underlying weight regain and obesity relapse, identify individuals at risk, and develop strategies for sustained weight loss and long-term weight maintenance. Yvonne Böttcher’ research group ( https://functionalgeneticsofobesity.wordpress.com/ ) is investigating the role of epigenetic mechanisms in obesity, the molecular mechanisms imposed by DNA, RNA and histone modifications and their potential interplay with genetic risk variants. In CORA, the group will specifically focus on the role of epigenetic memory in adipose tissue after weight loss. The project aims at investigating mechanisms involved in metabolic memory in human adipose tissue and weight re-gain after weight loss in humans. The candidate will be closely involved in collaborations with excellent clinical environments in Norway and abroad. The successful applicant will will work on amongst others on human biomaterial and cell culture models to better understand the potential epigenetic mechanisms responsible for weight regain. The work will include advanced molecular biology techniques such as next generation sequencing and multi-omics technologies as well as potentially single-cell technologies. The position will require collaboration both within Norway, and internationally, with clinicians, molecular biologists and bioinformaticians/statisticians in other areas of the centre. The successful candidate is expected to become a driver of the project in close Your areas of responsibility will be Carry out high-quality scientific research Publish results in high-impact, peer-reviewed scientific journals Apply for research funding Disseminate research at national and international meetings and conferences Co-Mentoring of PhD and mentoring of master students Qualifications and competence Qualification requirements: A degree equivalent to a Norwegian doctoral degree in molecular biology, biomedicine, genetics, or a closely related area. If the degree is not yet formally received, the doctoral dissertation must be submitted for evaluation by the application date. Only applicants with an approved doctoral thesis and public defense are eligible for employment Experience in epigenetics and/or obesity research Extensive experience in molecular biology laboratory work Hands-on experience in one or more of the following: Single cell sequencing techniques Omics techniques such as ChIP-seq, CUT & Run; CUT & Tag, ATAC-seq, Whole genome bisulphite sequencing, RNAseq, Nanopore sequencing, ribosome profiling Work with human adipose tissue or primary adipocytes and relevant cell culture models such as 3T3L-1 adipocytes or SGBS cells Next generation sequencing data analysis Excellent written and oral communication skills in English Published first author papers in well recognized journals It is an advantage if you have: Experience working with sensitive data in TSD Methodologal knowledge in cell sorting Basic programming skills (R/Python/Unix) Competence in statistics (R/SPSS/Stata) Personal characteristics Team player Self-driven/ independent Structured and well organized Good communication and collaboration skills Positive and enthusiastic Emp

Want to know if you're a fit? Check your CV against this role — free, in 30 seconds.

Similar jobs

• Oslo kommunes sentrale innkjøpsmiljø styrkes – vil du bli med på laget? · Anskaffelser og bærekraft, Oslo kommune, Økonomi- og forvaltningsetaten
• Ønsker du å bidra med å øke livskvaliteten til beboere innen rusomsorgen? · Blindern omsorgssenter, Oslo kommune, Velferdsetaten
• Pedagogisk leder · Kirsebærjordet barnehage, Oslo kommune, Bydel St. Hanshaugen
• Tannleger, 3 faste stillinger heltid · Aker tannklinikk, Oslo kommune, Helseetaten
• Radiografer søkes · Seksjon for radiografi angio/ultralyd/intervensjon, Rikshospitalet, Oslo universitetssykehus HF
• Tannhelsesekretær, 2 faste stillinger · Aker tannklinikk, Oslo kommune, Helseetaten